Chemistry

Prof. Alex Shalek and his colleagues developed a deep-learning model called DrugReflector aimed at speeding up the process of drug discovery, reports Heidi Ledford for Nature. “They used DrugReflector to find chemicals that can affect the generation of platelets and red blood cells — a characteristic that could be useful in treating some blood conditions,” explains Ledford. The researchers found that “DrugReflector was up to 17 times more effective at finding relevant compounds than standard, brute-force drug screening that depends on randomly selecting compounds from a chemical library.”

Researchers at MIT have uncovered remnants of “proto Earth,” which existed before a Mars-sized meteorite slammed into the Earth billions of years ago, reports Gayoung Lee for Gizmodo. The researchers “found an odd imbalance of potassium isotopes in ancient rock samples,” explains Lee. “Chemical analyses revealed the anomaly couldn’t have emerged from any known geological processes on modern Earth.” 

Using molecular evidence buried in rocks, researchers at MIT suggest that some of the Earth’s first living creatures are ancestors of the modern sea sponge, reports Ashley Fike for Vice. “The discovery suggests the earliest animals were simple, filter-feeding organisms that slowly cleaned the seas while the rest of the evolution was still figuring itself out,” says Fike. “These early sponges likely had no skeletons, nerves, or eyes – just porous bodies that absorbed water and nutrients. Yet they paved the way for everything that came next, from insects to mammals to us.” 

Writing for Forbes, Senior Lecturer Guadalupe Hayes-Mota '08, SM '16, MBA '16 emphasizes the importance of implementing ethical frameworks when developing AI systems designed for use in healthcare. “The future of AI in healthcare not only needs to be intelligent,” writes Hayes-Mota. “It needs to be trusted. And in healthcare, trust is the ultimate competitive edge.” 

MIT researchers have developed a new model that illustrates the chemical mechanisms underlying lithium-ion batteries, reports Gayoung Lee for Gizmodo. The findings could “lead to faster, more efficient batteries for electric vehicles, portable electronics, and more.”

A new study by MIT researchers suggests sea sponges may have been the “first animals to inhabit the Earth,” reports Maria Azzura Volpe for Newsweek. “In their work, the researchers linked so-called ‘chemical fossils’ found in ancient rocks to the ancestors of a class of modern-day sea sponges known as demosponges,” explains Volpe. “These chemical fossils—the molecular remnants of once-living organisms that have been buried, transformed, and preserved in sediment over time—were discovered in rocks that date back to more than 541 million years ago, during the Ediacaran Period.” 

MIT researchers have uncovered new evidence that suggests some of Earth’s first living creatures are ancestors of the modern sea sponge, reports Andrew Paul for Popular Science. The researchers identified 541 million-year-old chemical fossils embedded in sediment that they believe may indicate that some of Earth’s earliest creatures were the ancient relatives of today’s sea sponges. 

Researchers at MIT have proposed that liquids, such as ionic fluids, are “what’s important for extraterrestrial habitability, and not just water,” reports Gayoung Lee for Gizmodo. If confirmed, this research would “dramatically expand what’s considered the ‘habitable zone’ among known exoplanets,” writes Lee. “By current standards, the habitable zone is defined as the band within planetary systems in which liquid water can remain stable on the surface. When it comes to life, we’re understandably biased towards water; all life as we know it depends on it.”  

Jia Haojun PhD '24, graduate student Gao Wenhao and postdoctoral associate James Utama Surjadi have been named to the Forbes 30 and Under 30 Asia: Healthcare & Science list, writes Yue Wang for Forbes. The list honors those “who are using cutting-edge technology to innovative and improve their industry.”

Materials World reporter Sarah Morgan spotlights how MIT researchers have “combined the waterproof stickiness of mussel-inspired polymers with the germ-fighting properties of mucus-derived proteins, mucins, to form a cross-linking gel that strongly adheres to surfaces.” The new adhesive could be used to coat medical implants to prevent infection and bacteria build-up. Postdoc George Degen explains: “We demonstrate adhesion to wet tissue and metal-oxide surfaces, important substrates for biomedical applications. Moreover, our mucin-derived hydrogels discourage the formation of bacterial biofilms, raising the possibility of antifouling coatings.” 

MIT has been named among the top-performing intuitions in the QS World University Rankings by Subject 2024, reports The Economic Times. MIT ranks “first in 12 subjects, maintaining its stronghold in fields like engineering, technology, and computer science,” explains Economic Times. 

Prof. Sarah Millholland, Prof. Christian Wolf, Prof. Emil Verner, Prof. Darcy McRose, Prof. Marzyeh Ghassemi, Prof. Mohsen Ghaffari and Prof. Ariel Furst have received the 2025 Sloan Research Fellowship for “being among the most promising scientific researchers currently working in their fields,” reports Michael T. Nietzel for Forbes. “Sloan Research Fellows are chosen in seven scientific and technical fields—chemistry, computer science, Earth system science, economics, mathematics, neuroscience, and physics,” explains Nietzel. 

Prof. Desirée Plata speaks with C&EN reporter Prachi Patel about her work “trying to make our chemical processes and industries compatible with human and ecological health.” Says Plata of what she is most proud of in her work: “As professors, we produce papers and patents, but people are the most important thing we produce. The faculty of the world are training the next generation of researchers. There’s a perception right now that AI is going to solve all of our problems, but it cannot without good physical science information. We need a trained workforce. We need patient chemists who want to solve important problems.”

Researchers from MIT and elsewhere have developed a new vaccine that “could be potentially used against a broad array of coronaviruses like the one that causes Covid-19 and potentially forestall future pandemics,” reports Alex Knapp for Forbes. “The vaccine involves attaching tiny pieces of virus that remain unchanged across related strains to a nanoparticle,” explains Knapp.

MIT scientists have discovered a complex form of carbon, crucial for life on Earth, outside our solar system for the first time, demonstrating how “the compounds needed for life could come from space,” reports Alex Wilkins for New Scientist. “Now, we’re seeing both ends of this life cycle,” explains Prof. Brett McGuire. He explains that we can see the chemical archaeological record in our solar system in asteroids and on Earth, “and now we’re looking back in time at a place where another solar system will form, and seeing these same molecules there forming. We’re seeing the start of the archaeological record.”