A new assay developed by researchers from the Critical Analytics for Manufacturing Personalized-Medicine (CAMP), an Interdisciplinary Research Group (IRG) at the Singapore-MIT Alliance for Research and Technology (SMART), can profile the “rapidly changing host immune response in case of infection, in a departure from existing methods that focus on detecting the pathogens themselves,” reports the Scientific Inquirer.
Research affiliate Fei Chen and his colleagues have developed a new method that could be used to uncover the organization and sequence of DNA inside intact cells, reports Nature. The new method could be used to “help to reveal how genome organization changes with disease.”
European Pharmaceutical Review reporter Hannah Balfour writes that researchers from the Singapore-MIT Alliance for Research and Technology have developed a new dissolvable gelatin microcarrier that can help enhance cell production. “Innovations in microcarriers will aid in the scalability of certain cell types such as mesenchymal stromal cells for cell-based therapy, including for regenerative medicine applications,” says Associate Provost Krystyn Van Vliet.
Researchers from the Singapore-MIT Alliance for Research and Technology (SMART) Critical Analytics for Manufacturing Personalized Medicine (CAMP) research group have been awarded new research grants aimed at supporting work exploring personalized medicine and cell therapy, reports Health Europa. “In addition to our existing research on our three flagship projects, we hope to develop breakthroughs in manufacturing other cell therapy platforms that will enable better medical treatments and outcomes for society,” says Associate Provost Krystyn Van Vliet.
Prof. Aviv Regev speaks with the Associated Press about the Human Cell Atlas Consortium, which is aimed at cataloging all the cells in the human body in an effort to better understand human diseases. "This is not going to cure all disease immediately," she says, but "it is a critical stepping stone."
Prof. Aviv Regev speaks with NPR’s Nell Greenfieldboyce about her work with the Human Cell Atlas trying to catalogue every cell in the human body. “We don't need to analyze every individual cell out of 37 trillion because the cells kind of repeat themselves,” says Regev. “All we need to do is sample enough of them from enough region in order to get comprehensive coverage.”
STAT reporter Kate Sheridan writes about MIT startup SQZ Biotech, which is developing a “technology that will squeeze cells to open up tiny pores in their membranes to deliver gene therapies or medicines straight into the cell.”
Wired reporter Megan Molteni highlights Prof. Aviv Regev’s work leading the Human Cell Atlas, an effort to catalog the cells in the human body that could eventually serve as a roadmap for understanding and treating disease. “From the beginning we have designed this as a public good and an open resource to enable science around the world,” Regev explains.
Prof. Aviv Regev speaks with WBUR’s Karen Weintraub about her work exploring human cells. Regev says she was inspired to study the human cell as, “it’s this phenomenal entity that knows how to take many different pieces of information, make very quick and sophisticated decisions, act on them and continue on its way.”
The Human Cell Atlas, compiled by researchers at the Broad Institute of MIT and Harvard, has released its first batch of data with details of 530,000 immune system cells, writes Jason Daley of Smithsonian. New computational methods “allowed scientists to tackle… about 100 times as many cells as most cell-sequencing experiments handle,” explains Daley.
Boston Globe reporter Alyssa Meyers writes that MIT researchers have observed how the flu spreads between cells in the body. “Once it’s infected a cell and has commandeered its inner workings, the virus makes copies of itself that gather into buds attached to the membrane. The buds then break free from their host and go on to infect other cells.”
Nature reporter Anna Nowogrodzki spotlights Prof. Aviv Regev’s quest to map every cell in the human body. “One of the things that makes Aviv special is her enormous bandwidth. I've never met a scientist who thinks so deeply and so innovatively on so many things,” says Dana Pe'er, a computational biologist at Memorial Sloan Kettering Cancer Center.
Scientists at the Broad Institute are trying to map every cell in the human body, reports Sy Mukherjee for Fortune. Once complete, the human cell atlas could “ultimately tailor drug discovery and treatment to a person's genetic makeup,” explains Mukherjee.
Prof. Krystyn Van Vliet speaks with Samantha Boh of The Straits Times. Van Vliet explains that "My work gives me added motivation because at the end of the day you are not just engineering a new toy or learning something for yourself, but engineering a whole process where the outcome has the potential to restore health."
Louis Columbus of Forbes writes about MIT Technology Review’s 2017 list of technological breakthroughs, which features several innovations from MIT researchers. Featured MIT research includes a new solar cell design that could double the efficiency of conventional solar cells, and the Cell Atlas, an initiative to catalog every cell type in the human body.