Bryan Marquard writes for The Boston Globe about Prof. Susan Lindquist, one of the most honored scientists in the nation, who died on Oct. 27. “She did not want to do an experiment unless she thought it would deliver deep biological impact and make a difference to the world,” said Dr. Vikram Khurana of Yumanity Therapeutics.
Prof. Susan Lindquist, a former director of the Whitehead Institute known for her “conceptually daring work with yeast proteins,” died on Oct. 27, writes William Grimes for The New York Times. Her research “demonstrated that protein-folding errors occurred in all species and that biological changes could be passed from one generation to the next through proteins alone.”
STAT reporter Meghana Keshavan speaks with Prof. Guoping Feng about his new research that shows glial cells “very actively participate in direct neuronal function — particularly in the brain areas that control appetite, energy and metabolism.” The findings could help spur the development of weight loss medications.
Ian Sample of The Guardian writes that the Human Cell Atlas project, which will be co-led by the Broad Institute, aims to map the cells in the human body . “This will have a substantial impact on our scientific understanding and as a result, on our ability to diagnose, monitor and treat disease,” says Prof. Aviv Regev.
Researchers from the Broad Institute will co-lead an initiative aimed at mapping and describing every cell in the human body, writes Kate Kelland of Reuters. "We now have the tools to understand what we are composed of, which allows us to learn how our bodies work, and uncover how all these elements malfunction in disease," explains Prof. Aviv Regev.
MIT researchers have developed a portable system that could produce biotech drugs on demand, reports Lisa Rapaport for Reuters. “The table-top machine has the potential to one day produce proteins to treat any number of a wide range of conditions like cancer, diabetes, heart attacks, and hemophilia,” writes Rapaport.
Prof. Susan Lindquist has been named a recipient of the Albany Medical Center Prize in Medicine and Biomedical Research, according to the AP. Lindquist’s research has raised hopes that “treatments could prevent protein ‘misfolding’ that drives degenerative conditions like Alzheimer's, Parkinson's and Lou Gehrig's disease.”
A portable device developed by MIT researchers uses programmable yeast to create drugs on demand, reports Jamie Ducharme for Boston Magazine. The device “could be a lifesaver for doctors working in vulnerable conditions, such as the battlefield, a remote village, or even an ambulance,” writes Ducharme.
MIT researchers have developed a programmable vaccine that could be used to respond to disease outbreaks, reports Ben Gruber for Reuters. The vaccine harnesses “messenger RNA, a genetic material that can be programmed to fight any viral, bacterial or parasitic disease by provoking an amplified immune response.”
Popular Science reporter Samantha Cole writes that MIT researchers have developed a laptop-sized, portable device that can produce biopharmaceuticals for doctors in remote locations. Cole explains that the device can “produce a single dose of treatment with a series of steps, using genetically engineered yeast cells as a mini 'factory' for a variety of customizable drugs.”
Boston Herald reporter Lindsay Kalter writes that MIT researchers have developed a portable pharmacy that can manufacture biopharmaceuticals and modify treatments. “Instead of relying on a cocktail that already exists, you can reprogram the reactor on demand to customize the treatment,” says Prof. Timothy Lu.
Prof. Linda Griffith speaks with Wired reporter Sarah Zhang about her work developing chips that can mimic human organs in an effort to better understand interactions between the immune system and the liver. Griffith is currently working to connect at least 10 miniature organs on a chip to study, for example, how breast cancer can spread to the liver.
MIT researchers have found that plants may use prions, the proteins responsible for mad cow disease, to form memories, reports Anil Ananthaswamy for New Scientist. “Prions, we think, are responsible for some really broad, really interesting biology,” says Prof. Susan Lindquist. “We have only seen the tip of the iceberg so far.”
Huffington Post reporter Carolyn Gregoire writes that MIT spinoff Synlogic is working on reprogramming gut bacteria to act as a living therapeutic. “It’s become really clear that the bacteria living in us and on us affect our bodies in a variety of different ways — in ways that we never imagined,” explains Prof. Timothy Lu.
STAT reporter Eric Boodman spotlights Prof. Jing-Ke Weng’s work searching for medical treatments in plants. Boodman writes that Weng is “determined to harness peanut skins, and twisted roots, and an herb known as horny goat weed...to treat human disease."