Biological engineering

Researchers from MIT and elsewhere have used artificial intelligence to develop a new antibiotic to address Acinetobacter baumannii, a bacteria known for infecting wounds, lungs and kidneys, reports Harland-Dunaway for The World.

Using a machine-learning algorithm, researchers from MIT and McMaster University have discovered a new type of antibiotic that works against a type of drug-resistant bacteria, reports Brenda Goodman for CNN. Goodman notes that the compound “worked in a way that stymied only the problem pathogen. It didn’t seem to kill the many other species of beneficial bacteria that live in the gut or on the skin, making it a rare narrowly targeted agent.”

Researchers from MIT and McMaster University used a machine-learning algorithm to identify a new antibiotic that can treat a bacteria that causes deadly infections, reports Maya Yang for The Guardian. The researchers used an “AI algorithm to screen thousands of antibacterial molecules in an attempt to predict new structural classes. As a result of the AI screening, researchers were able to identify a new antibacterial compound which they named abaucin,” writes Yang.

Prof. Jongyoon Han and research scientist Junghyo Yoon have developed a new portable desalination device that can deliver safe drinking water at the push of a button, reports Meghan Gunn and Kerri Anne Renzulli for Newsweek. The device “requires less power than a cell phone charger to run and produces clean drinking water that exceeds World Health Organization standards,” writes Gunn and Renzulli.

Ginkgo Bioworks, a biotech company founded by Jason Kelly BS ’03, PhD ’08, Reshma Shetty PhD ‘08, Barry Canton PhD ’08, Austin Che PhD ’08 and Professor Tom Knight, is working to develop synthetic fragrances, reports Scott Kirsner for The Boston Globe.

Callie Gade and Nate Bonham of CNN’s Discovery Daily Podcast spotlight how researchers from MIT developed a 3D printed replica of the human heart that can help doctors customize treatments for patients before conducting open heart surgery or other intrusive procedures. “These more patient-specific heart replicas can help future researchers develop and identify treatments for people with unique health problems,” says Gade.

Researchers at the McGovern and Broad Institutes have developed a bacterial "nanosyringe" that can inject large proteins into specific cells in the body, which could lead to safer and more effective treatments for a variety of conditions, including cancer, reports Michael Le Page for New Scientist. “The fact that this can load a diversity of different payloads of different sizes makes it unique amongst protein delivery devices,” says graduate student Joseph Kreitz.

Ingrid Wickelgren at Scientific American highlights a new study from researchers at the McGovern and Broad Institutes, in which they used a bacterial ‘nanosyringe’ to inject large proteins into human cells. “The syringe technology also holds promise for treating cancer because it can be engineered to attach to receptors on certain cancer cells,” writes Wickelgren.     

IEEE Pulse reporter Leslie Mertz spotlights Prof. Ed Boyden’s work on refining expansion microscopy. “My hope for expansion, looking 5 or 10 years out, is that it could help produce a map of molecules that is detailed enough to help us understand life itself,” says Boyden.

Dr. Akshay Syal, a medical fellow for NBC News, discusses how MIT researchers have developed a new technique to 3D print custom replicas of the human heart.

Using an artificial intelligence system, researchers at MIT and elsewhere have developed a new Covid-19 vaccine that could be effective against current and future strains, reports Gwen Egan for Boston.com. “The vaccine differs from others currently on the market due to the portion of the virus being targeted,” writes Egan.  

Boston Globe reporter Hiawatha Bray writes that MIT researchers have used an AI system to identify a potential new Covid-19 vaccine that may be effective against both current and future variants of the virus. “The new vaccine targets a portion of the COVID virus that is much less prone to evolve,” writes Bray. “That could potentially make it effective against many different versions of the virus, eliminating the need for routine booster shots.”

MIT researchers have developed a new approach to vaccines that uses “a machine learning twist [that] could put an end to boosters and seasonal variant shots,” reports Devin Coldewey for TechCrunch.

Researchers at MIT developed a system that uses artificial intelligence to help predict future risk of developing breast cancer, reports Poppy Harlow for CNN. What this work does “is identifies risk. It can tell a woman that you’re at high risk for developing breast cancer before you develop breast cancer,” says Larry Norton, medical director of the Lauder Breast Center at the Memorial Sloan Kettering Cancer Center.

Boston Globe reporter Ryan Cross spotlights Chroma Medicine, a biotech startup co-founded by MIT researchers that is “developing a new class of gene editing technologies that could control how our genetic code is read without changing the code itself.” Cross explains that Chroma Medicine’s technology could “have broad applications for treating both rare and common diseases.”