Biological engineering

Cognito Therapeutics, founded by Prof. Ed Boyden and Prof. Li-Huei Tsai, has secured a large-scale trial to test a new device aimed at treating Alzheimer’s disease, reports Sarah McBride for Bloomberg.

Jake Becraft PhD ’19 and former postdoctoral associate Tasuku Kitada co-founded Strand Therapeutics, a biotech firm developing mRNA therapies for cancer, reports Ryan Cross for The Boston Globe. They created “a way to activate mRNA in the presence of particular microRNAs – a much more useful application for therapies,” writes Cross. 

Research from Synlogic, a biotech company founded by Profs James Collins and Timothy Lu, has found that it’s the company’s engineered bacteria could provide some benefit to patients with a rare genetic disease, reports Emily Mullin for Wired. “Similar to how you might program a computer, we can tinker with the DNA of bacteria and have them do things like produce a drug at the right time and the right place, or in this case, break down a toxic metabolite,” says Lu.

CNBC reporter Catherine Clifford spotlights C16 Biosciences, a startup co-founded by MIT alumni that is developing a palm oil alternative called Palmless. “What we are building is a platform technology that can produce all different kinds of microbial oils,” explains David Heller ’18, co-founder and head of operations at C16 Biosciences. “It’s definitely possible that we’re able to make other kinds of vegetable oil replacements in the future.” 

Writing for The Boston Globe, Prof. Linda Griffith underscores the pressing need to invest in studying women’s health and menstruation science. “These were the attitudes society had about breast cancer decades ago; we didn’t talk about it. But then we finally focused on the science, and overcame the squeamishness about mentioning ‘breasts’ by creating a technical language that could be spoken without hesitation by anyone,” writes Griffith. “We need a similar scientific push for menstruation science, and a comfort level with the language that goes with it. It’s time.”

Researchers from MIT’s Research Laboratory for Electronics have developed a portable desalinator that can turn seawater into safe drinking water, reports Ian Mount for Fortune. Research scientist Jongyoon Han and graduate student Bruce Crawford have created Nona Technologies to commercialize the product, writes Mount.

Lawrence A. Tabak, who is currently performing the duties of the NIH Director, spotlights a new study by Prof. James Collins and his colleagues aimed at exploring the potential of AI to streamline the process of selecting new antibiotics. “In future studies, the Collins lab will continue to incorporate and train the computers on even more biochemical and biophysical data to help with the predictive process," Tabak writes. "That’s why this study should be interpreted as an interim progress report on an area of science that will only get better with time.”

MIT researchers have “developed a free-floating desalination unit consisting of a multilayer evaporator that recycles the heat generated when the water vapor condenses, boosting its overall efficiency,” reports Nell Lewis for CNN. “Researchers suggested it could be configured as a floating panel on the sea, delivering freshwater through pipes to the shore, or it could be designed to serve a single household, using it atop a tank of seawater,” writes Lewis.

Prof. Edward Boyden has developed a new imaging technique called expansion-revealing microscopy that can reveal tiny protein structures in tissues, reports The Economist. “Already his team at MIT has used it to reveal detail in synapses, the nanometer-sized junctions between nerve cells, and also to shed light on the mechanisms at play in Alzheimer’s disease, revealing occasional spirals of amyloid-beta protein around axons, which are the threadlike parts of nerve cells that carry electrical impulses.”

Professor Eric Alm speaks with Claire Ainsworth at New Scientist about studying wastewater to better understand the health, wealth and environment of various communities. “It’s not about going in and taking a measurement,” said Alm. “It’s about developing a platform that can help you reach insights about what’s going on.”

Researchers from MIT and Harvard have developed a “3D-printed ‘lab-on-a-chip’ that could detect Covid-19 immunity levels and Covid infections from saliva within two hours,” reports Ben Leonard and Ruth Reader for Politico.

Researchers from MIT and other institutions have developed a postcard-sized test that can detect a Covid-19 infection and the presence of antibodies resulting from an infection, reports Maddie Bender for the Daily Beast.  “What excites me about this diagnostic device is that it combines a high level of accuracy with a flexible design that could make it a major tool in our arsenal for addressing future pandemics,” explains Prof. James Collins.

Wired reporter Maggie Chen spotlights Prof. Katharina Ribbeck and her lab’s work deconstructing how glycans hidden inside mucus can work to keep specific organisms healthy. Glycans “can be beneficial – assisting in food digestion, regulating immunity, and protecting against germs – but that can be harmful if they outcompete one another or become virulent, potentially leading to infection,” writes Chen.

Researchers at MIT have developed a wood-like plant material which could eventually serve as a viable wood substitute in various construction projects, reports Tim Newcomb for Popular Mechanics. Researchers adjust “chemicals in the growth process to precisely control the physical and mechanical properties, such as stiffness and density,” explains Newcomb.

Instructor Natalie Kuldell writes for The Boston Globe about the importance of creating more workplace learning opportunities for high school students. “Without question, every career decision I’ve made has been influenced by that first summer internship, guiding my choice of undergraduate major, my doctoral thesis, my postdoctoral fellowship, and then my academic and teaching life,” writes Kuldell.