Popular Science reporter Samantha Cole writes that MIT researchers have developed a laptop-sized, portable device that can produce biopharmaceuticals for doctors in remote locations. Cole explains that the device can “produce a single dose of treatment with a series of steps, using genetically engineered yeast cells as a mini 'factory' for a variety of customizable drugs.”
Boston Herald reporter Lindsay Kalter writes that MIT researchers have developed a portable pharmacy that can manufacture biopharmaceuticals and modify treatments. “Instead of relying on a cocktail that already exists, you can reprogram the reactor on demand to customize the treatment,” says Prof. Timothy Lu.
Prof. Linda Griffith speaks with Wired reporter Sarah Zhang about her work developing chips that can mimic human organs in an effort to better understand interactions between the immune system and the liver. Griffith is currently working to connect at least 10 miniature organs on a chip to study, for example, how breast cancer can spread to the liver.
MIT researchers have discovered that a bacterium found in the human mouth can be used to form a new CRISPR gene-editing system that can target RNA, reports Carl Zimmer for The New York Times. The development “may open up a new front in gene engineering, gaining the ability to precisely adjust the proteins in cells, for instance, or to target cancer cells."
New Scientist reporter Colin Barras writes that MIT researchers have found they can program C2c2, an enzyme found in bacteria, to serve as an RNA-editing tool. Barras writes that the tool “promises to transform our understanding of RNA’s role in our growth and development, and provide a new avenue for treating infectious diseases and cancer.”
Michael Le Page writes for New Scientist that MIT researchers have developed a technique that allows cells to log their activities using the CRISPR gene-editing system. Le Page explains that “such CRISPR-based logging could have a huge range of uses, from smart cells that monitor our health from within, to helping us understand exactly how our bodies develop.”
In an article for The Huffington Post, Susan Blumenthal highlights how researchers from MIT have developed a paper-based test for diagnosing the Zika virus. Blumenthal writes that “the test consists of a paper covered with yellow dots that turns purple in the presence of the RNA of the virus.”
Huffington Post reporter Carolyn Gregoire writes that MIT spinoff Synlogic is working on reprogramming gut bacteria to act as a living therapeutic. “It’s become really clear that the bacteria living in us and on us affect our bodies in a variety of different ways — in ways that we never imagined,” explains Prof. Timothy Lu.
MIT researchers have developed a programming language that allows users to design DNA circuits for living cells, writes Andy Coghlan for New Scientist. “We take the same approach as for designing an electronic chip,” says Prof. Christopher Voigt. “Every step in the process is the same – it’s just that instead of mapping the circuit to silicon, it’s mapped to DNA.”
Christopher Intagliata reports for Scientific American about the programming language Prof. Christopher Voigt’s team developed for living cells. Intagliata explains that, “the researchers used the platform to design 60 genetic circuits, which they then ran inside E. coli bacteria. Many of these DNA-based circuits allow bacteria to sense environmental data…and respond in various ways.”
MIT researchers have developed a programming language for living cells, reports Erika Check Hayden for Nature. “What we’re finding over time is that biology isn’t this kind of mysterious unpredictable substrate; it just felt that way because we didn’t really have the tools to see what was going on,” Prof. Christopher Voigt says.
Prof. Feng Zhang has been named a recipient of the 2016 Canada Gairdner International Award for his work on the development of the CRISPR gene-editing system, reports CBC News. CRISPR "may prove to be a ‘powerful therapeutic’ for treating human diseases by editing out harmful genetic mutations.”
Globe and Mail reporter Ivan Semeniuk spotlights Prof. Feng Zhang and his role in developing the CRISPR-Cas9 gene-editing system, for which he was honored as a recipient of the 2016 Canada Gairdner International award. “CRISPR genome editing technology is a really powerful platform,” says Zhang. “It think it will advance both our ability to understand disease and to develop treatments.”
MIT researchers have found evidence that there may be windows of opportunity during which drugs are more effective at treating cancer, reports Ariana Eunjung Cha for The Washington Post. "If we know the route to resistance," explains Prof. Michael Hemann, "we can ambush tumor cells."
In this “Science of Innovation” segment, NBC Learn explores Prof. Angela Belcher’s work using viruses engineered in her laboratory to form nanoscale wires for tiny batteries. “By harnessing nature’s own processes, Angela Belcher has been able to turn today’s viruses into tomorrow’s batteries.”