Originally created by the Zhang Lab in 2017, CRISPR tool SHERLOCK has been improved upon to be three times more sensitive for detecting viruses and infections using an inexpensive test strip. Sharon Begley writes for STAT News, “A paper strip, like in a pregnancy test, is dipped into a sample, and if a line appears, the target molecule was detected — no instruments required.”
A gene-editing tool called SHERLOCK, developed in Prof. Feng Zhang’s lab, allows for faster detection of infections and viruses, such as Zika and Dengue fever. “It does this by combining different types of CRISPR enzymes, which are unleashed together to target distinct bits of DNA and RNA, another of the major biological molecules found in all forms of life,” writes Alessandra Potenza for The Verge.
MIT researchers have discovered a new family of viruses in the ocean that appears to play a key role in ocean ecosystems and could help provide insights on how viruses evolve, reports Marin Finucane for The Boston Globe. Finucane explains that the findings could also lead to, "a better understanding of human biology.”
The Boston Globe Magazine highlights two MIT spinoffs in a list spotlighting 19 bold new ideas and fresh faces from 2017. Startup Ministry of Supply, which creates custom apparel using high-tech design, has made “getting a great-fitting blazer...a seamless experience,” while another startup, Biobot, has begun analyzing sewer waste to determine which communities are most affected by opioids.
MIT spinout Ginkgo Bioworks has not only maintained its founding members, but also recently raised $275 million from investors, writes Matthew Herper for Forbes. Herper predicts that excitement surrounding synthetic biology companies will continue because “private money is getting excited about the idea of designing biology.”
MIT researchers have developed a new technique to 3-D print genetically engineered bacteria into a variety of shapes and forms, reports Karen Hao for Quartz. The technique could eventually be used to develop such devices as, “an ingestible living robot that secretes the correct drug when it detects a tumor.”
MIT engineers have developed a method to 3-D print living cells into tattoos and 3-D structures, reports Danny Paez for Inverse. Paez explains that the researchers believe the technique, “could possibly be used to create a ‘living computer,’ or a structure made up of living cells that can do the stuff your laptop can.”
Co.Design reporter Katharine Schwab writes that MIT researchers have developed a tattoo made of living cells that activate when exposed to different kinds of stimuli. Schwab explains that in the future the tattoos could be designed, “so that they respond to environmental pollutants or changes in temperature.”
A new study by MIT researchers provides evidence that antibiotics can change the body’s chemistry and make it more hospitable to bacteria, reports Melinda Wenner Moyer for Scientific American. “We suspect that the strength of this effect will really depend on the type of infection and types of antibiotics used,” explains postdoc Jason Yang.
Prof. Timothy Lu speaks with STAT reporter Eric Boodman about his work trying to harness bacteria to treat disease. Lu notes that his lab is also currently working on, “building these genetic circuits for therapeutic applications, but instead of targeting bacteria, we’ve been focused on using human cells.”
MIT researchers have developed a new material that harvests sunlight and converts it into energy, reports Sydney Pereira for Newsweek. “Inspired by the structures that plants use to gather sunlight and turn it into energy, the material mimics circuitry found in nature for harvesting light,” Pereira explains.
Boston Globe reporter Alyssa Meyers writes that a new study by MIT researchers shows that probiotics could be used to help fight high blood pressure. The researchers found that probiotics, “can boost beneficial bacteria in the human gut that prevent pro-inflammatory immune cells from increasing in number." Pro-inflammatory immune cells have been linked with hypertension.
Prof. Feng Zhang and his colleagues have created a CRISPR-based system that can edit RNA in human cells, reports Amy Dockser Marcus for The Wall Street Journal. “The new RNA-editing system, which the scientists have dubbed Repair, allows the editing of individual RNA letters, correcting a common mutation known to play a role in a number of diseases.”
Financial Times reporter Clive Cookson writes that Prof. Feng Zhang and his colleagues have engineered CRISPR so that it can edit single RNA letters in human cells. Cookson explains that the researchers believe that, “RNA editing offers a safer and more flexible way to make corrections than the permanent changes involved in DNA editing.”
Prof. Feng Zhang has been awarded the Lemelson-MIT Prize, reports Sharon Begley for STAT. Zhang was honored for his, “track record of innovations and of coming up with big ideas that change fields,” explains Prof. Michael Cima, faculty director of the award. “Zhang is one of those individuals who move through groups of talented people sparking new ideas.”