MIT researchers have “used an algorithm to sort through millions of genomes to find new, rare types of CRISPR systems that could eventually be adapted into genome-editing tools,” writes Sara Reardon for Nature. “We are just amazed at the diversity of CRISPR systems,” says Prof. Feng Zhang. “Doing this analysis kind of allows us to kill two birds with one stone: both study biology and also potentially find useful things.”
Researchers from MIT and elsewhere have “genetically engineered bacteria to efficiently turn plastic waste into useful chemicals,” reports Aristos Georgiou for Newsweek. MIT Prof. James Collins and University of Illinois Urbana-Champaign Prof. Ting Lu explain that they see two potential applications for their work. "In the former case, plastic waste collected from oceans and landfills would be transported to a facility where it would be bioprocessed with engineered microbes,” they note. “In our latter scenario, these microbes could be deployed directly in lands or oceans to bio-transform plastic debris in situ.”
Ginkgo Bioworks, a biotech company founded by Jason Kelly BS ’03, PhD ’08, Reshma Shetty PhD ‘08, Barry Canton PhD ’08, Austin Che PhD ’08 and Professor Tom Knight, is working to develop synthetic fragrances, reports Scott Kirsner for The Boston Globe.
Researchers at the McGovern and Broad Institutes have developed a bacterial "nanosyringe" that can inject large proteins into specific cells in the body, which could lead to safer and more effective treatments for a variety of conditions, including cancer, reports Michael Le Page for New Scientist. “The fact that this can load a diversity of different payloads of different sizes makes it unique amongst protein delivery devices,” says graduate student Joseph Kreitz.
Ingrid Wickelgren at Scientific American highlights a new study from researchers at the McGovern and Broad Institutes, in which they used a bacterial ‘nanosyringe’ to inject large proteins into human cells. “The syringe technology also holds promise for treating cancer because it can be engineered to attach to receptors on certain cancer cells,” writes Wickelgren.
Research from Synlogic, a biotech company founded by Profs James Collins and Timothy Lu, has found that it’s the company’s engineered bacteria could provide some benefit to patients with a rare genetic disease, reports Emily Mullin for Wired. “Similar to how you might program a computer, we can tinker with the DNA of bacteria and have them do things like produce a drug at the right time and the right place, or in this case, break down a toxic metabolite,” says Lu.
Forbes contributor David Bressan writes that a new study by MIT researchers proposes that oxygen began accumulating in early Earth’s atmosphere due to interactions between marine microbes and minerals in ocean sediments. The researchers hypothesize that “these interactions helped prevent oxygen from being consumed, setting off a self-amplifying process where more and more oxygen was made available to accumulate in the atmosphere,” writes Bressan.
New York Times reporter Veronique Greenwood writes that Prof. Tami Lieberman examined the human skin and found that each pore had a single variety of Cutibacterium acnes bacteria living inside. “Each person’s skin had a unique combination of strains, but what surprised the researchers most was that each pore housed a single variety of C. acnes,” writes Greenwood. “The pores were different from their neighbors, too — there was no clear pattern uniting the pores of the left cheek or forehead across the volunteers, for instance.”
Researchers from MIT have developed a 3-D printable ink made from bacterial cells that can release anti-cancer drugs or remove toxins from the environment, reports Carissa Wong for New Scientist. This is the first of its kind,” says research affiliate Avinash Manjula-Basavanna. “A living ink that can respond to the environment. We have repurposed the matrix that these bacteria normally utilise as a shielding material to form a bio-ink.”
New York Times reporter Steve Lohr spotlights the origin and history of MIT startup Gingko Bioworks, a synthetic biology company founded with a “shared belief that biology could be made more like computing with reusable code and standard tools instead of the bespoke experiments of traditional biology." Jason Kelly ’03, PhD ’08, one of the founders of MIT startup Ginkgo Bioworks and the company’s chief executive, explains that “the ultimate goal for Ginkgo is to make it as easy to program a cell as it is to program a computer.”
Ginkgo Bioworks founders Jason Kelly PhD ’08, S.B. ’03 and Reshma Shetty PhD ’08 speak with Boston Globe reporter Scott Kirsner about the inspiration for and growth of the company, which is focused on manipulating genetic material to get living cells to perform new jobs. Shetty notes that the Ginkgo Bioworks team is “dedicated to making biology easier to engineer."
A new exhibition at the Design Museum in London showcases sneaker design, including the work of several MIT researchers, reports Elizabeth Paton for The New York Times. A sneaker designed by researchers from MIT and Puma “is home to microorganisms that can learn a user’s specific heat emissions and opens up ventilation based on those patterns.”
Financial Times reporter Ellie Pithers spotlights the contributions of several teams of MIT researchers to the future of sneaker design, currently on display at the London Design Museum. The “Breathing Show,” which was developed by designers from the MIT Design Lab and Puma, “is made from a molded material that contains cavities filled with bacteria; responding to heat generated by the foot, the bacteria eats away at the material to create a hole that allows air to enter and circulate.”
MIT researchers have created a new filter from tree branches that could provide an inexpensive, biodegradable, low-tech option for water purification, writes Shaena Montanari for Popular Science. “We hope that our work empowers such people to further develop and commercialize xylem water filters tailored to local needs to benefit communities around the world,” says Prof. Rohit Karnik.
New Scientist reporter Layal Liverpool writes that a new study co-authored by MIT researchers finds that “synthetic cells made by combining components of Mycoplasma bacteria with a chemically synthesised genome can grow and divide into cells of uniform shape and size, just like most natural bacterial cells.”