New technologies reveal cross-cutting breakdowns in Alzheimer’s disease
“Single-cell profiling” is helping neuroscientists see how disease affects major brain cell types and identify common, potentially targetable pathways.
Alzheimer’s risk gene undermines insulation of brain’s “wiring”
In people carrying APOE4, a key brain cell mismanages cholesterol needed to insulate neurons properly — another sign APOE4 contributes to disease by disrupting brain lipids.
Honoring work to support innovation in aging
MIT AgeLab co-hosts 10th anniversary celebration of Boston Bridge, a longtime collaborator offering development, networking, career growth, and mentorship in the field of aging.
With fractured genomes, Alzheimer’s neurons call for help
Study indicates ailing neurons may instigate an inflammatory response from the brain’s microglia immune cells.
MIT AgeLab awards five scholarships to students who further intergenerational connections
OMEGA scholarships encourage bonds between younger and older adults.
Envisioning new financing models to mitigate the crisis in long-term care
Mel King Community Fellows from MIT's Community Innovators Lab meet in Berlin to examine the German elder care model.
Helping older adults stay safe and independent
MIT alumni-founded WalkWise uses a motion-detecting device for walkers to allow family members and care professionals to monitor adults with mobility challenges.
MIT research informs design of new coordination service for family caregivers
Program supports family caregivers with dedicated service coordinators based on learning from MIT's AgeLab.
Three distinct brain circuits in the thalamus contribute to Parkinson’s symptoms
Targeting these circuits could offer a new way to reverse motor dysfunction and depression in Parkinson’s patients.
Students imagine better products, services, and infrastructure for an aging society
Projects from a new MIT urban studies and planning course speak to the impact of increased longevity on systems and markets.
Chemists reveal how tau proteins form tangles
Two types of tau proteins mix together in a nearly random way to generate the tangles seen in the brains of Alzheimer’s patients.
New research center focused on brain-body relationship established at MIT
K. Lisa Yang Brain-Body Center to investigate the brain’s complex relationship with other body systems.
A brain circuit in the thalamus helps us hold information in mind
This circuit, which weakens with age, could offer a target to help prevent age-related decline in spatial memory.
Aging Brain Initiative awards fund five new ideas to study, fight neurodegeneration
Competitive seed grants launch yearlong investigations of novel hypotheses about potential causes, biomarkers, treatments of Alzheimer’s and ALS.
In Down syndrome cells, genome-wide disruptions mimic a senescence-like state
Extra chromosome alters chromosomal conformation and DNA accessibility in neural progenitor cells; study establishes senescence as a potentially targetable mechanism for future treatment.