Broad Institute

Scientists at the Broad Institute of MIT and Harvard have “identified key genetic traits that for the first time point to a biological mechanism behind schizophrenia,” writes Shirley Wang of The Wall Street Journal.

In an article for The Boston Globe’s special section about the 2015 Bostonians of the Year, Sharon Begley writes about the work of Prof. Feng Zhang. Begley writes that Zhang, "is one of the world’s most creative and influential biological engineers, able to see possibilities where others don’t.”

BBC News reporter Michelle Roberts writes that MIT researchers have fine-tuned the CRISPR-Cas9 genome editing system to make it safer and more accurate. This development is "vital if it [CRISPR] is to be used in humans to cure inherited diseases or inborn errors,” explains Roberts. 

In an article for The New Yorker, Michael Specter writes about Prof. Feng Zhang and his work with CRISPR. Specter writes that Zhang was first inspired to pursue a career in science when he attended Saturday morning molecular biology classes as a middle school student. Zhang recalls that the class, “really opened my imagination.” 

STAT reporter Sharon Begley profiles Prof. Feng Zhang. Begley writes that Zhang’s “discoveries could finally bring cures for some of the greatest causes of human suffering, from autism and schizophrenia to cancer and blindness.”

Juan Enriquez writes for Wired that the intersection of Vassar and Main Streets is one of the most innovative areas in the world, highlighting how MIT plays a leading role in sparking innovation. Enriquez writes that this area “may generate one per cent to two per cent of the future global economy.”

The Broad Institute Foundry, a synthetic biology lab, has been awarded a new grant from DARPA to pursue research on engineering cells in an effort to “find better treatments for disease, make new biofuels, or create fabrics woven with life,” reports Alexandra Ossola for Popular Science. 

Alexandra Ossola writes for Popular Science that MIT researchers have found a molecule that could make the CRISPR gene-editing technique more precise. The new molecule “makes the editing process easier to control and could create new possibilities for how scientists can edit DNA in the future.”

Boston Globe reporter Sharon Begley writes that Prof. Feng Zhang has uncovered enzymes that could be used to edit genes more precisely than the proteins currently used by CRISPR. Begley explains that the discovery means that CRISPR could become an “even more powerful tool to reveal the genetic defects underlying diseases and to perhaps repair them.”

In an article for Wired, Sarah Zhang writes that MIT researchers have identified a new gene-editing system that could prove more effective than current techniques. The new system involves, “a different protein that also edits human DNA, and, in some cases, it may work even better than Cas9,” the protein used for DNA editing.

Lloyd Mallinson reports for Boston.com that researchers from MIT and Harvard have discovered the link between obesity and genetics. “The uncovered cellular circuits may allow us to dial a metabolic master switch for both risk and non-risk individuals, as a means to counter environmental, lifestyle, or genetic contributors to obesity,” explains Prof. Manolis Kellis.

Prof. Manolis Kellis speaks with BBC reporter Andrew Peach about the discovery of a genetic “master switch” inside fat cells. This switch “decides whether every time we have a meal the excess calories will be stored as fat or whether they will actually be burned away as heat,” explains Kellis.

Prof. Manolis Kellis and his colleagues have discovered a metabolic switch linked to obesity, reports Chukwuma Muanya for The Guardian. “Obesity has traditionally been seen as the result of an imbalance between the amount of food we eat and how much we exercise, but this view ignores the contribution of genetics to each individual’s metabolism,” explains Kellis.

“Researchers at MIT and Harvard Medical School have analysed the genetics behind obesity,” writes Natasha Hinde for The Huffington Post. “They discovered a new pathway that controls human metabolism by prompting fat cells to store fat or burn it away.”

Andy Coghlan reports for New Scientist that MIT researchers have found a gene that determines whether fat cells store or burn energy. “You could say we’ve found fat cells’ radiator, and how to turn it up or down,” says Prof. Manolis Kellis.