Murcko is responsible for the strategic evaluation, identification and integration of new, disruptive technologies into worldwide research and development. Joining Vertex as a founding scientist in 1990, he started the company's molecular modeling, bioinformatics, IS and chemoinformatics groups.
He is a co-inventor of Vertex's first two marketed drugs, Agenerase and Lexiva, both HIV protease inhibitors. From 1987-1990, he was at Merck, where he helped discover multiple clinical candidates against cardiovascular and ocular diseases, including inhibitors of the enzyme carbonic anhydrase for the treatment of glaucoma. For more information contact Linda Earle at lkn[at]mit.edu or 617-324-2297; or visit http://web.mit.edu/biology/www/giving/vertexday09.html.