A new technique could accelerate the development of RNA therapies
MIT chemical engineers found a way to rapidly produce lipid nanoparticles of varying sizes, which could make it easier to develop new vaccines and therapeutics.
Unmasking “zombie cells” in aging tissue with an AI-powered barcode
Tracking down senescent cells, which accumulate as we age, could help diagnose age-related disorders and guide researchers working on new treatments.
Flipping the script on biology education, and scaling it up
Using a modular kit, the MIT Edgerton Center is bringing a hands-on biology curriculum to Massachusetts’ second-largest school district.
DNA shaper steers nervous system development
A study of worms finds a protein that helps shape the structure of the genome is critical for establishing the identity of some neurons.
Scientists unveil more than 600 new tissue models of human cancer
Derived from patient tumor samples and available to researchers around the world, the cells will aid the development of new cancer treatments.
Rett syndrome study highlights potential for personalized treatments
Using advanced human cell cultures, MIT researchers tracked how two different mutations alter neural circuit development, and how each could be addressed with distinct potential therapeutics.
How chromatin movement helps control gene expression
By monitoring these chromosomal structures over many timescales, MIT researchers found that chromatin helps bring genes closer to their regulatory elements.
Study: Gene circuits reshape DNA folding and affect how genes are expressed
When genes are transcribed, they suppress or activate their neighbors, coupling expression between the two genes.
Brain circuit needed to incorporate new information may be linked to schizophrenia
Impairments of this circuit may help to explain why some people with schizophrenia lose touch with reality.
3 Questions: Building predictive models to characterize tumor progression
Assistant Professor Matthew Jones is working to decode molecular processes on the genetic, epigenetic, and microenvironment levels to anticipate how and when tumors evolve to resist treatment.
AI to help researchers see the bigger picture in cell biology
By providing holistic information on a cell, an AI-driven method could help scientists better understand disease mechanisms and plan experiments.
New AI model could cut the costs of developing protein drugs
MIT researchers used a large language model to optimize the genetic sequences of proteins manufactured by yeast, making production more efficient.
Designing the future of metabolic health through tissue-selective drug delivery
Founded by three MIT alumni, Gensaic uses AI-guided protein design to deliver RNA and other therapeutic molecules to specific cells or areas of the body.
3 Questions: Using computation to study the world’s best single-celled chemists
Assistant Professor Yunha Hwang utilizes microbial genomes to examine the language of biology. Her appointment reflects MIT’s commitment to exploring the intersection of genetics research and AI.
A better DNA material for genetic medicine
With its circular single-stranded DNA molecules, MIT spinout Kano Therapeutics plans to make gene and cell therapies safer and more effective.