Prof. Feng Zhang and his colleagues have created a CRISPR-based system that can edit RNA in human cells, reports Amy Dockser Marcus for The Wall Street Journal. “The new RNA-editing system, which the scientists have dubbed Repair, allows the editing of individual RNA letters, correcting a common mutation known to play a role in a number of diseases.”
Financial Times reporter Clive Cookson writes that Prof. Feng Zhang and his colleagues have engineered CRISPR so that it can edit single RNA letters in human cells. Cookson explains that the researchers believe that, “RNA editing offers a safer and more flexible way to make corrections than the permanent changes involved in DNA editing.”
Prof. Feng Zhang has been awarded the Lemelson-MIT Prize, reports Sharon Begley for STAT. Zhang was honored for his, “track record of innovations and of coming up with big ideas that change fields,” explains Prof. Michael Cima, faculty director of the award. “Zhang is one of those individuals who move through groups of talented people sparking new ideas.”
Prof. Feng Zhang has been honored as one of the recipients of this year’s Albany Medical Center Prize in Medicine and Biomedical Research for his work contributing to the development of the gene-editing tool CRISPR-Cas9, according to the AP. The AP notes that CRISPR-Cas9, “has sparked a boom in research over the past five years.”
TIME reporter Alice Park writes that MIT researchers have modified the CRISPR gene-editing system so that it could be used to diagnose disease. Park explains that the researchers, “used CRISPR to recognize specific substances that bacteria and viruses make. Picking up even the slightest whisper of these products can alert doctors that an infection is active.”
MIT researchers have developed a new technique that uses the CRISPR gene-editing system to diagnose diseases, reports Joel Achenbach for The Washington Post. Achenbach explains that the tool could potentially be used to “detect not only viral and bacterial diseases but also potentially for finding cancer-causing mutations.”
Broad Institute research affiliate Theresa Oei, who is also a cheerleader for the Patriots, speaks with Boston Globe reporter Steve Annear about her passion for science and for dance. Oei, who currently works in Prof. Feng Zhang’s lab developing genome editing techniques, explains that while she has enjoyed cheerleading, “in the end, I see science as my vocation.”
MIT researchers have discovered that a bacterium found in the human mouth can be used to form a new CRISPR gene-editing system that can target RNA, reports Carl Zimmer for The New York Times. The development “may open up a new front in gene engineering, gaining the ability to precisely adjust the proteins in cells, for instance, or to target cancer cells."
New Scientist reporter Colin Barras writes that MIT researchers have found they can program C2c2, an enzyme found in bacteria, to serve as an RNA-editing tool. Barras writes that the tool “promises to transform our understanding of RNA’s role in our growth and development, and provide a new avenue for treating infectious diseases and cancer.”
Prof. Feng Zhang has been named a recipient of the 2016 Canada Gairdner International Award for his work on the development of the CRISPR gene-editing system, reports CBC News. CRISPR "may prove to be a ‘powerful therapeutic’ for treating human diseases by editing out harmful genetic mutations.”
Globe and Mail reporter Ivan Semeniuk spotlights Prof. Feng Zhang and his role in developing the CRISPR-Cas9 gene-editing system, for which he was honored as a recipient of the 2016 Canada Gairdner International award. “CRISPR genome editing technology is a really powerful platform,” says Zhang. “It think it will advance both our ability to understand disease and to develop treatments.”
BBC News reporter Michelle Roberts writes that MIT researchers have fine-tuned the CRISPR-Cas9 genome editing system to make it safer and more accurate. This development is "vital if it [CRISPR] is to be used in humans to cure inherited diseases or inborn errors,” explains Roberts.
Alexandra Ossola writes for Popular Science that MIT researchers have found a molecule that could make the CRISPR gene-editing technique more precise. The new molecule “makes the editing process easier to control and could create new possibilities for how scientists can edit DNA in the future.”
Boston Globe reporter Sharon Begley writes that Prof. Feng Zhang has uncovered enzymes that could be used to edit genes more precisely than the proteins currently used by CRISPR. Begley explains that the discovery means that CRISPR could become an “even more powerful tool to reveal the genetic defects underlying diseases and to perhaps repair them.”
In an article for Wired, Sarah Zhang writes that MIT researchers have identified a new gene-editing system that could prove more effective than current techniques. The new system involves, “a different protein that also edits human DNA, and, in some cases, it may work even better than Cas9,” the protein used for DNA editing.