Researchers at MIT and elsewhere have developed a machine-learning model that can identify which drugs should not be taken together, reports Politico. “The researchers built a model to measure how intestinal tissue absorbed certain commonly used drugs,” they write. “They then trained a machine-learning algorithm based on their new data and existing drug databases, teaching the new algorithm to predict which drugs would interact with which transporter proteins.”
Institute Prof. Robert Langer speaks with Freakonomics host Stephen Dubner about his approach to failure and perseverance in his professional career. Langer recalls how despite early failures with developing new drug delivery methods, “I really believed that if we could do this, it would make a big difference in science, and I hoped a big difference in medicine.”
Researchers at MIT have developed a mobile vaccine printer capable of printing a vaccine onto a patch of microneedles that can be absorbed into the skin without injection, reports Sandra Tsing for NPR. “These printed vaccines could be used in areas that are unable to refrigerate traditional vaccines,” explains Tsing.
Researchers at MIT have developed a wearable patch that can allow drugs to pass through the skin using ultrasonic sound waves, reports Sandra Tsing for NPR. “The researchers say their lightweight design allows for reliable use on the go,” says Tsing. “This could treat skin conditions, both medical or cosmetic.”
Principal Research Scientist Ana Jaklenec speaks with CBC host Bob McDonald about her work developing a mobile vaccine printer. The device “can be very important in certain scenarios when you’re trying to bring the ability to vaccinate in areas that might not have the right infrastructure to make vaccines or even to administer vaccines,” says Jaklenec, “so I think the portability is key here.”
Researchers at MIT have developed a mobile printer that could create microneedle patches for mRNA vaccine delivery. “These "microneedle patches" offer a range of advantages over traditional jabs in the arm, including that they can be self-administered, are relatively painless, could be more palatable to the vaccine-hesitant and can be stored at room temperature for long periods of time,” writes Daniel Lawler for Agence France-Presse.
Research scientist Ana Jaklenec spoke with Jonathan Grinstein at Genetic Engineering & Biotechnology News about a new microneedle patch printer she and her colleagues have developed that may one day enable on-demand vaccine manufacturing. “The idea was that you could, in an emergency situation, deploy some of these printers and locally vaccinate the population to prevent the global spread of infection,” says Jaklenec.
Researchers at the McGovern and Broad Institutes have developed a bacterial "nanosyringe" that can inject large proteins into specific cells in the body, which could lead to safer and more effective treatments for a variety of conditions, including cancer, reports Michael Le Page for New Scientist. “The fact that this can load a diversity of different payloads of different sizes makes it unique amongst protein delivery devices,” says graduate student Joseph Kreitz.
Ingrid Wickelgren at Scientific American highlights a new study from researchers at the McGovern and Broad Institutes, in which they used a bacterial ‘nanosyringe’ to inject large proteins into human cells. “The syringe technology also holds promise for treating cancer because it can be engineered to attach to receptors on certain cancer cells,” writes Wickelgren.
National Geographic reporter Maya Wei-Haas explores how the ancient art of origami is being applied to fields such a robotics, medicine and space exploration. Wei-Haas notes that Prof. Daniela Rus and her team developed a robot that can fold to fit inside a pill capsule, while Prof. Erik Demaine has designed complex, curving fold patterns. “You get these really impressive 3D forms with very simple creasing,” says Demaine.
MIT researchers are developing targeted drug delivery through the use of nanoparticles to aid in cancer treatment, reports Simone Migliori for Boston Magazine. “Designed to circulate through the bloodstream, these small but mighty travelers [nanoparticles] can deliver a chemotherapy drug directly to a target cancer cell without disturbing any healthy cells along the way,” writes Migliori. “In doing so, patients may be able to avoid some of the worst side effects of chemotherapy drugs while still effectively treating their cancer.”
MIT researchers have created a robotic pill that can safely penetrate the mucus barrier in the digestive tract to deliver drugs more efficiently, reports Margaret Osborne for Smithsonian Magazine. “The device’s textured surface clears away the mucus, and the rotating motion erodes the compartment with the drug payload, which slowly releases into the digestive tract,” explains Osborne.
New Scientist reporter Alex Wilkins writes that MIT researchers have developed a robotic pill that can propel itself through mucus in the intestines and could enable some injection-only medications to be taken orally. “The pill is 2.5-centimeters long and 1-centimeter wide – about the size of a large multivitamin – and encased in a gelatin capsule that dissolves in stomach acid,” writes Wilkins. “The pH in the lower intestine activates the motor, which is powered by a small battery.”
Doctoral research specialist Morteza Sarmadi speaks with Emily Henderson from News Medical Life Sciences about his work with Prof. Robert Langer and research scientist Ana Jaklenec in developing microparticles that are able to deliver self-boosting vaccines. “We believe this technique can significantly reduce the need to visit a healthcare provider to receive booster shots, a major challenge in remote areas without sophisticated healthcare resources,” says Sarmadi.
Scientists at MIT are developing a self-boosting vaccine that can provide multiple doses of a vaccine via a single injection, reports Darko Manevski for Newsweek. The technology “could be particularly useful for administering childhood vaccinations in regions where people do not have regular access to medical care,” writes Manevski.