• Images show calcium ion influx into neurons as a result of magnetothermal excitation with alternating magnetic fields in the presence of magnetic nanoparticles.

    Images show calcium ion influx into neurons as a result of magnetothermal excitation with alternating magnetic fields in the presence of magnetic nanoparticles.

    Courtesy of the researchers

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Magnetic brain stimulation

Images show calcium ion influx into neurons as a result of magnetothermal excitation with alternating magnetic fields in the presence of magnetic nanoparticles.

New technique could lead to long-lasting localized stimulation of brain tissue without external connections. Watch Video


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Researchers at MIT have developed a method to stimulate brain tissue using external magnetic fields and injected magnetic nanoparticles — a technique allowing direct stimulation of neurons, which could be an effective treatment for a variety of neurological diseases, without the need for implants or external connections.

The research, conducted by Polina Anikeeva, an assistant professor of materials science and engineering, graduate student Ritchie Chen, and three others, has been published in the journal Science.

Previous efforts to stimulate the brain using pulses of electricity have proven effective in reducing or eliminating tremors associated with Parkinson’s disease, but the treatment has remained a last resort because it requires highly invasive implanted wires that connect to a power source outside the brain.

“In the future, our technique may provide an implant-free means to provide brain stimulation and mapping,” Anikeeva says.

In their study, the team injected magnetic iron oxide particles just 22 nanometers in diameter into the brain. When exposed to an external alternating magnetic field — which can penetrate deep inside biological tissues — these particles rapidly heat up.

The resulting local temperature increase can then lead to neural activation by triggering heat-sensitive capsaicin receptors — the same proteins that the body uses to detect both actual heat and the “heat” of spicy foods. (Capsaicin is the chemical that gives hot peppers their searing taste.) Anikeeva’s team used viral gene delivery to induce the sensitivity to heat in selected neurons in the brain.

This video shows a calcium ion influx into neurons as a result of magnetothermal excitation with alternating magnetic fields in the presence of magnetic nanoparticles. Neurons on the right have been heat-sensitized with the capsaicin receptor TRPV1; neurons on the left have not.

Courtesy of the researchers

The particles, which have virtually no interaction with biological tissues except when heated, tend to remain where they’re placed, allowing for long-term treatment without the need for further invasive procedures.

“The nanoparticles integrate into the tissue and remain largely intact,” Anikeeva says. “Then, that region can be stimulated at will by externally applying an alternating magnetic field. The goal for us was to figure out whether we could deliver stimuli to the nervous system in a wireless and noninvasive way.”

The new work has proven that the approach is feasible, but much work remains to turn this proof-of-concept into a practical method for brain research or clinical treatment.

The use of magnetic fields and injected particles has been an active area of cancer research; the thought is that this approach could destroy cancer cells by heating them. “The new technique is derived, in part, from that research,” Anikeeva says. “By calibrating the delivered thermal dosage, we can excite neurons without killing them. The magnetic nanoparticles also have been used for decades as contrast agents in MRI scans, so they are considered relatively safe in the human body.”

The team developed ways to make the particles with precisely controlled sizes and shapes, in order to maximize their interaction with the applied alternating magnetic field. They also developed devices to deliver the applied magnetic field: Existing devices for cancer treatment — intended to produce much more intense heating — were far too big and energy-inefficient for this application.

The next step toward making this a practical technology for clinical use in humans “is to understand better how our method works through neural recordings and behavioral experiments, and assess whether there are any other side effects to tissues in the affected area,” Anikeeva says.

This is “a completely novel approach for deep-brain stimulation,” says Bianxiao Cui, an assistant professor of chemistry at Stanford University who was not involved in this research. “The new method is significant in that it is relatively more easily administered and induces less brain-tissue responses as compared with electrode implantation. More importantly, the stimulation could be remotely controlled, a highly appealing feature for deep-brain stimulation.”

In addition to Anikeeva and Chen, the research team also included postdoc Gabriela Romero, graduate student Michael Christiansen, and undergraduate Alan Mohr. The work was funded by the Defense Advanced Research Projects Agency, MIT’s McGovern Institute for Brain Research, and the National Science Foundation.


Topics: Research, School of Engineering, Materials Science and Engineering, Research Laboratory of Electronics, Nanoscience and nanotechnology, Brain and cognitive sciences, National Science Foundation (NSF), Defense Advanced Research Projects Agency (DARPA)

Comments

the deepest thinking and contemplating has much powerful influence to construct the immune capacity to protect from deseas, most probably it relates to the brain and immune system. I observe the people who they have hallucination and such mental problem which related to the thinking, imagination and mad, they cure themselves without the medication(l meant the physical disease even high pneumonia) . so the feelings depend to the mutation of immune system. for instance if u have an anticipated thought during the time of ur sickness, u should meet the either particular doctor or a special hospital, u should go to that particular hospital, not only that, it shall not be cured, this is the mental status of black magic and sick healing

Mit is a piece of future at the present time . I hope to visit Mit in my lifetime.

It will not react to external magnetic field in the environment?

during the time of thinking and imagining there is a electric short circuit between the neurons, it is triggered to the creation of much powerful waves., such as the hyperpoarazation and deplorsxation in the neurons transmission in the nerves system. but it is not sure it is the influence of positive thoughts

I'm 57 now suffering from dystonia since 2001. When I'm reading such study
It makes me dream that one day I could recover and live again.
Please don't stop your good work. I'm ready to try it anytime.
Christine

biggest( largest in size ) brain owned people can think beyond the skill of common human, I ll say an example, have you ever thought about other three universe ( another three universe it will be called emag world ) light cant be reached, mean the universe without light and space. the common human cant think, so their brain structure is neuron oriented I mean iconic memory ( vision and light ), Synapisis, Nero fire can be made very soon by largest brain rather than common Brain.

then if you are thinking of the largest brain oriented animal Elephants and Whales, they have less skill than human, but Elephants can hear the raining sounds over the 250 klm, Whales have navigation skill, and much hearing capacity than human, but it dosent mean that smallest brain have low rate iq skill everybody knows about the geometry skill of honey bee and honeycomb ( I do a paper on Geometry of Lights waves which i have been taught from honeybee)
but my arguments are largest brains ( in human ) have much capacity of contemplating so their neurotransmitter, denrites in neuron relate to highy speed neoro fire in synapses , and much longest memory ( hippocampus ) hemispheres, and Anteroir cingulate cortex ( thinking, feeling and hearo-automatic memory

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