• Two areas of the brain — the hippocampus (yellow) and the prefrontal cortex (blue) — use two different brain-wave frequencies to communicate as the brain learns to associate unrelated objects.

    Two areas of the brain — the hippocampus (yellow) and the prefrontal cortex (blue) — use two different brain-wave frequencies to communicate as the brain learns to associate unrelated objects.

    Illustration: Jose-Luis Olivares/MIT

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How brain waves guide memory formation

Two areas of the brain — the hippocampus (yellow) and the prefrontal cortex (blue) — use two different brain-wave frequencies to communicate as the brain learns to associate unrelated objects.

Neurons hum at different frequencies to tell the brain which memories it should store.


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Our brains generate a constant hum of activity: As neurons fire, they produce brain waves that oscillate at different frequencies. Long thought to be merely a byproduct of neuron activity, recent studies suggest that these waves may play a critical role in communication between different parts of the brain.

A new study from MIT neuroscientists adds to that evidence. The researchers found that two brain regions that are key to learning — the hippocampus and the prefrontal cortex — use two different brain-wave frequencies to communicate as the brain learns to associate unrelated objects. Whenever the brain correctly links the objects, the waves oscillate at a higher frequency, called “beta,” and when the guess is incorrect, the waves oscillate at a lower “theta” frequency.

“It’s like you’re playing a computer game and you get a ding when you get it right, and a buzz when you get it wrong. These two areas of the brain are playing two different ‘notes’ for correct guesses and wrong guesses,” says Earl Miller, the Picower Professor of Neuroscience, a member of MIT’s Picower Institute for Learning and Memory, and senior author of a paper describing the findings in the Feb. 23 online edition of Nature Neuroscience.

Furthermore, these oscillations may reinforce the correct guesses while repressing the incorrect guesses, helping the brain learn new information, the researchers say.

Signaling right and wrong

Miller and lead author Scott Brincat, a research scientist at the Picower Institute, examined activity in the brain as it forms a type of memory called explicit memory — memory for facts and events. This includes linkages between items such as names and faces, or between a location and an event that took place there.

During the learning task, animals were shown pairs of images and gradually learned, through trial and error, which pairs went together. Each correct response was signaled with a reward.

As the researchers recorded brain waves in the hippocampus and the prefrontal cortex during this task, they noticed that the waves occurred at different frequencies depending on whether the correct or incorrect response was given. When the guess was correct, the waves occurred in the beta frequency, about 9 to 16 hertz (cycles per second). When incorrect, the waves oscillated in the theta frequency, about 2 to 6 hertz.

Previous studies by MIT’s Mark Bear, also a member of the Picower Institute, have found that stimulating neurons in brain slices at beta frequencies strengthens the connections between the neurons, while stimulating the neurons at theta frequencies weakens the connections.

Miller believes the same thing is happening during this learning task.

“When the animal guesses correctly, the brain hums at the correct answer note, and that frequency reinforces the strengthening of connections,” he says. “When the animal guesses incorrectly, the ‘wrong’ buzzer buzzes, and that frequency is what weakens connections, so it’s basically telling the brain to forget about what it just did.”

The findings represent a major step in revealing how memories are formed, says Howard Eichenbaum, director of the Center for Memory and Brain at Boston University.

“This study offers a very specific, detailed story about the role of different directions of flow, who’s sending information to whom, at what frequencies, and how that feedback contributes to memory formation,” says Eichenbaum, who was not part of the research team.

The study also highlights the significance of brain waves in cognitive function, which has only recently been discovered by Miller and others.

“Brain waves had been ignored for decades in neuroscience. It’s been thought of as the humming of a car engine,” Miller says. “What we’re discovering through this experiment and others is that these brain waves may be the infrastructure that supports neural communication.”

Enhancing memory

The researchers are now investigating whether they can speed up learning by delivering noninvasive electrical stimulation that oscillates at beta frequencies when the correct answer is given and at theta frequencies when the incorrect answer is given. “The idea is that you make the correct guesses feel more correct to the brain, and the incorrect guesses feel more incorrect,” Miller says.

This form of very low voltage electrical stimulation has already been approved for use in humans.

“This is a technique that people have used in humans, so if it works, it could potentially have clinical relevance for enhancing memory or treating neurological disorders,” Brincat says.

The research was funded by the National Institute of Mental Health and the Picower Foundation.


Topics: Brain and cognitive sciences, Picower Institute for Learning and Memory, Research, School of Science, Mental health, Memory

Comments

Your "hippocampus" in yellow is actually a white matter fiber bundle called the corpus callosum.

my research proves that the silence brain communication with waves in birds, I have seen also the dreams ( if u have been dreaming at night that particular dream u suppose to be heard a song, or sound that dream will be recollected forever) in the case of deafness also they hear the sound in their dream that y my research is still progressing on between memory, hearing and brain waves

in the Anthropological history of the human, The Homo Neaderthal who resided in the central Asia and Europe before the 2000000 years ago, they were large brain oriented animal, they had special additional ability in the vision at night and the olfactory sense. but it was extincted in the evaluation chain circle. paradoxically in homo sapinas, and in the Salvo Sickens hippocampuses became much powerful, so the evaluated electric neurons retrieve the memories with the electric power waves.

Is the neuroanatomy figure fact-checker on a snow day?

The human brain has the amazing ability to transform and store through brainwave everything is captured through the neuronal cells located in the vision. I believe that the vision also contribute. Congratulations!

Listen to the audio version of this article at https://umano.me/c/jZRyZ/how-b...

how about a link to the paper, MIT media peoples?

but vision doesn't have power to make automatic memory ( echo waves) I mean ( echoic memory ), for instance, you aren't taught in childhood any grammatical rules and regulation, but at the age of 2, you speak on the basis of grammatical rules in your mother-tong, owing to that echoic memory( hearing) is much powerful than iconic memory. thanks

so hearing memory relates to the hearoutomatic memory ( in my perception I called this particular name )

A link to the paper "Frequency-specific hippocampal-prefrontal interactions during associative learning" is available at Miller's page here https://earlkmiller.org/2015/0...

Intelligent Sleep uses brainwave entrainment, binaural beats, and other therapies based on frequency vibrations in its RestSpa and seminars. It's good to see MIT researchers extend the study of brainwaves into the process of learning and memory creation. See http://www.mhealthtalk.com/bra....

Please inform me about a lengthy professional visit to research MIT neuroscience.
Sincerely, jsalmon403@gmail.com

Keep this in mind. Just remember the KISS (keep it simple stupid) I have a thought/theory that all this is. (Those are the calculations of Inductive and deductive thought?) be mindful of those that are your impulse and learn away?

Constant Cortisol Release (Extreme Stress-long term) inhibits memory and learning - in my experience..Will eventual release of the CPTSD Stress bring back the learning ability, memory retention ?? Math ability seems to have disappeared ???

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